In article <CJKznL.675 at news.udel.edu>, mcdonald at strauss.udel.edu (John H McDonald) writes:
> In article <2h3qjm$24m at hahn.informatik.hu-berlin.de>,
> Dirk Balfanz <balfanz at informatik.hu-berlin.de> wrote:
>>>>has anybody out there got any figures from any recent publications, or
>>even old (if reliable) that show heterozygozity of the human genome for
>>1) protein coding sequences (exons)
>>2) intervening sequences (introns)
>>3) noncoding regions
>> Li, W-H. and L.A. Sadler. 1991. Low nucleotide diversity in man. Genetics
> 129: 513-523.
>> The authors of this paper looked through the databanks for genes that had
> been sequenced more than once, and came up with estimates of nucleotide
> diversity for exons, introns, etc. One of the take-home messages was that
> nucleotide diversity in humans was very poorly known. I don't know if
> there are more recent papers on the subject.
>> John H. McDonald
> Department of Biology
> University of Delaware
>
I believe that the Li and Sadler paper is probably documenting sequencing
errors rather than heterozygosity.
--
Tom Bickle
Microbiology Dept, Biozentrum, Basel University
Klingelbergstrasse 70, CH-4056 Basel, Switzerland
+ 41 61 267 21 20 bickle at urz.unibas.ch
