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John Drake has been collecting and computing mutation rates in
different organisms. He can be reached at:
Laboratory for Molecular Genetics
E3-01, NIEHS
PO Box 12233
Research Triangle Park
NC 27709-2233
Tel: (919) 541-3361
Philip Harriman, NSF
Where can I find tables of naturally occurring mutation rates?
I want to know:
What is the ratio of C -> T mutations : A -> G mutations in
various species?
Is the excess rate of C -> T mutations completely accounted
for by CpG methylation? Or is that only part of the reason for
an elevated rate of C -> T compared to A -> G?
What are the ranges of values for the ratio of silent mutations
within coding regions to amino acid-substituting mutations? i.e.
if I find 703 mutations in a gene between species A and species B and only 3
amino acid changes in the proteins of species A and B, is this very
unusual?
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* Brian Foley * If we knew what we were doing *
* Molecular Genetics Dept. * it wouldn't be called research *
* University of Vermont * *
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