I've been struggling with a question on population-genetics, and
I very much doubt that I am the first one to run into this question.
Does anyone know how the expected frequency of a specific nucleotide
(or allele), and the distribution of this expected frequency
depend on the mutation frequency in a case of neutral evolution.
Kimura describes the change in
the frequency-distribution in absence of mutations, but this (of course)
allways goes to fixation. I need a formula that both includes mutations
and genetic drift.
any help would be highly appreciated.
Martijn A. Huynen email: mah at t10.lanl.gov
Mail Stop K 710 (work) phone: (505)667-9455 (work)
Theoretical Biology, T-10
Los Alamos National Laboratory Fax: (505)665-3493
Los Alamos, NM 87545