Genetic Drift vs. Mutations

Martijn A. Huynen mah at primer.lanl.gov
Thu Apr 13 12:10:53 EST 1995


I've been struggling with a question on population-genetics, and
I very much doubt that I am the first one to run into this question.

Does anyone know how the expected frequency of a specific nucleotide
(or allele), and the  distribution of this expected frequency
 depend on the mutation frequency in a case of neutral evolution.
Kimura describes the change in
the frequency-distribution in absence of mutations, but this (of course)
allways goes to fixation. I need a formula that both includes mutations
and genetic drift.

any help would be highly appreciated.

Martijn A. Huynen                          email: mah at t10.lanl.gov
Mail Stop K 710  (work)                    phone: (505)667-9455 (work)
Theoretical Biology, T-10
Los Alamos National Laboratory             Fax:   (505)665-3493
Los Alamos, NM 87545

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