In article <3fneba$m73 at decaxp.harvard.edu>
robison at lipid.harvard.edu (Keith Robison) writes:
>Ram Samudrala (ram at mbisgi.umd.edu) wrote:
>: I'd like to know if there's a database or listing of families of genes
>: that occur in a single DNA molecule (a single chromosome or plasmid).
>There's no shortage of what you are looking for. [...]
>Vertebrate immunoglobulin genes are arrayed in large clusters,
>and many of these have been sequenced (or in a similar vein,
>large stretches of the human T-cell receptor loci have been
>completely sequenced). Homeobox genes are another example of
>local duplications.
Can't help but chuckle that the examples of historical priority --
rDNA, globin, and histone genes -- were omitted in favor of these other
valid examples. The molecular, biochemical, & genetic data supporting
gene families in eukaryotes, even with tandem-array organization, began
to appear long before DNA cloning & sequencing, and certainly long before
genome-projects arose as technical possibilities.
A classic pre-cloning reference on eukaryotic gene families is
the review by Hood, Campbell & Elgin (1975) Ann. Rev. Genetics 9: 305-353.
Mark
--
Mark D. Garfinkel (e-mail: garfinkl at iitmax.acc.iit.edu)
My views are my own, which is why they're copyright 1995 (c)
I post from here only because of miscellaneous news problems there.
