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DNA vs amino acid sequences

Christopher L. Schardl clscha00 at ukcc.uky.edu
Thu Jun 15 10:01:52 EST 1995

GC bias is, of course, very important because it can fool both the 
algorithms used to generate trees, and most of the methods to 
statistically evaluate those trees. However, there are methods to 
identify and correct for such bias:

Steel, M. A., Lockhart, P. J., and Penny, D., 1993  Confidence in 
evolutionary trees from biological sequence data. Nature 364: 440-442.

Lockhart, P. J., Steel, M. A., Hendy, M. D., and Penny, D., 1994  
Recovering evolutionary trees under a more realistic model of sequence 
evolution. Molecular Biology and Evolution 11: 605-612.


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