gene clusters

Richard Gordon gordonr at cc.UManitoba.CA
Fri May 19 06:54:08 EST 1995

Dear David,

I've formulated the concept of a "gene module", a set of genes used by 
more than one step of differentiation, in:

Gordon, R. (1995). The Hierarchical Genome and Differentiation Waves: 
Novel Unification of Development, Genetics, and Evolution (Singapore: 
World Scientific), in prep.

Might this match your clusters? To what extent are you dealing with 
"housekeeping" genes? To what extent are they related via gene duplication?

Best regards, -Dick Gordon, U.Manitoba[May19,95]

On 18 May 1995, David H. Griffin wrote:

> Is anyone looking at the evolution of genome organization, specifically
> clustering of genes with related functions. This has been reported
> frequently among fungi, but these clusters are not always universal,
> for example the proline genes of Aspergillus nidulans are clustered but
> those of Saccharomyces cerevisiae are not. Is gene clustering of
> physiologically related genes common amongst other organisms than
> fungi? Any examples with references, or at least investigators names
> that I can readily search would be appreciated. Any ideas on the
> evolutionary basis?
> Gene clusters that I know about:
> proline utilization in Aspergillus nidulans 
> sporulation specific genes in Aspergillus nidulans 
> quinic acid utilization in Neurospora crassa 
> galactose utilization in Saccharomyces cerevisiae and Kluveromyces
> lactis
> some, but not all histone genes of Saccharomyces cerevisiae 
> penicillin biosynthesis in Penicillium chrysogenum 
> sterigmatocystin biosynthesis in Aspergillus nidulans 
> aflatoxin biosynthesis in Aspergillus parasiticus ?
> David H. Griffin
> Department of Environmental & Forest Biology
> College of Environmental Science and Forestry
> 350 Illick Hall
> One Forestry Drive
> Syracuse NY 13210-2788
> e-mail: griffin at mailbox.syr.edu

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