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testing if seqs. are in same phylo. tree?

Jonathan Eisen jeisen at leland.stanford.edu
Fri Nov 10 15:30:46 EST 1995

Regarding David Maddison's question about convergent evolution and how 
to determine if genes are part of the same tree or not:

R. Doolittle had a review in TIBS last year about such issues. 

In addition there is some published work relating to this question from 
people working on in-vitro directed evolution.  In these studies, 
regions of genes or entire genes can either be replced by random 
sequences or mutagenized at very high rates.  These genes can then be 
selected for specific functions (such as catalytic RNA activity or DNA 
binding activity of the encoded protein).  Thus these systems can be 
used to determine how easy it is to converge on the same sequence by 
strong selection. Specifically Larry Loeb and colleagues at U. 
Washington have done some work relating to this (e.g., see Gene 
137:41-47).  Not all of the people doing such work have addressed the 
issue of convergence but there is probably a lot of information in their 
studies that might be of relevance.

Jonathan A. Eisen
Department of Biological Sciences
Stanford University
Stanford, CA  94305-5020
jeisen at leland.stanford.edu

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