The Serine Shift

Shane McKee shane at reservoir.win-uk.net
Fri Sep 15 15:38:49 EST 1995

In article <437ce6$6to at hecate.umd.edu>,
 Ram Samudrala (ram at mbisgi.umd.edu) writes:

 (I wrote)
>>Sorry if it seems like a bizarre question, but my own feeling is
>>that the codons ought to be conserved even between widely
>>differing species.
>I don't see any reason for this immediately... my feeling is that
>selection occurs at the protein level, and therefore, as long as the
>mRNA translation leads to a serine, I don't think the organism will
>care much.    

I think you misunderstand my point, which was that to get from one
group of codons to the other requires a double-point-mutation,
which would (presumably) be pretty rare. If examples of the Serine
Shift (or Switch) are common, then it might have implications for
our understanding of mutagenesis.

I agree that as long as the protein is OK, the organism is
unlikely to care which codon is there.

Shane McKee (SHO, RVH, Belfast)  | /      Art becomes science when
Shane at reservoir.win-uk.net     --O--    you start trying to figure
                               / |  out what the heck you're doing

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