mtDNA integration into the nuclear genome

higgins at ebi.ac.uk higgins at ebi.ac.uk
Mon Sep 18 05:36:56 EST 1995

In article <01HV2R1MTH4I8Y665K at gnv.ifas.ufl.edu>, CAMP at GNV.IFAS.UFL.EDU (Don Campton) writes:
> Dear colleagues,
> Please suggest references (original research papers, reviews, etc.) 
> documenting the integration of mtDNA genes or sequences (e.g. D-loop)
> into the nuclear genome, especially of vertebrates.  I am referring to
> potential instances where the same or similar sequence (perhaps the
> entire 16kb homologous sequence) occurs in both genomes.  This 
> obviously would create PCR problems if one did not do a cell fractionation
> step or CsCl separation of the two genomes prior to amplification.  Your
> help will be appreciated.  Thanks.
> Don Campton
> Department of Fisheries and Aquatic Sciences
> University of Florida

Hi Don:

sorry for the delay in replying.  Steven J. O'Brien and colleagues
have found half of a mitochondrial genome integrated into the nuclear
genome of some cats (felidae).  It looks like it is behaving like a big 
pseudogene and they have found no transcripts from it.  

I have no references to this stuff I am afraid.  


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