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% GC content and 16S phylogeny

Patrick Keeling pkeeling at is.dal.ca
Mon Aug 5 07:21:15 EST 1996

I think it may a bit more complex than simply yes or no. James McInterney 
makes an interesting point about the lack of correlation in Sulfolobus, 
but there are other cases where the 16S is lower in GC than the genome in 
general. There may be a general correlation in most cases, but there are 
certainly enough exceptions to warrent being very careful about such 

Of course I dont have a single reference to back this up either, but if 
you look at the halophile 16S genes and genomes, I think they bear this 
out anecdotally.


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