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Maximum Likelihood Analysis Question

Mark Siddall mes at vims.edu
Tue Aug 20 00:45:57 EST 1996

Ron Kagan wrote:
> For those of you who have used maximum likelihood analysis (DNAML and
> DNAMLK of Felsenstein's Phylip package): What level of significance do
> you use for the likelihood ratio between the log likelihoods w and w/o
> the molecular clock, to reject the null hypothesis of the molecular
> clock?  Is p<0.05 still the standard, or should I use a stricter criteria
> (p<0.01)?

Since when is the molecular clock a reasonable null hypothesis?!!!

Molecular phylogenetics in the late 20th century... limited by the 
arbitrariness of Joe Felsenstein's imagination and Linus Pauling's 

[no offense Joe... ].


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