Friends:
Last spring I announced a new theory on the origin of life and
its disparity on earth by the title "Independent Birth of
Organisms." Subsequently, during spring and summer, an
extensive discussion went on in sci.bio.evolution,
bionet.molbio.evolution and other related
forums on this theory.
One of the major bottlenecks that the conventional evolution
theory has to go through is that it cannot show how even one
contiguous gene of the assumed original ancestral prokaryote-like
cell could originate probabilistically on earth. Furthermore, only
if contiguous genes could originate in the first place, could the
introns be inserted into them later. I have countered that
assumption, and have shown that it is the split-genes that are
typically eukaryote-like that originated directly in the random
primordial DNA sequences, wherein they occurred essentially
fully-formed, and that the eukaryote-like cells were formed
directly from the genomes that assembled from these genes.
If this is true, then we should be able to show that the split-genes
typical of eukaryotes could easily and abundantly occur within a
reasonably small amount of random primordial DNA material.
I have provided extensive computational simulation experiments
in my book "Independent Birth of Organisms," demonstrating this
premise. Now Jeff Mattox, who was a strong supporter of my
theory during the internet discussions last summer, has made
available a web site, where users can interactively search for any
given "gene" in a reasonably short random DNA sequence. The
gene will be in split form, and you will search for many different
exons in pieces, just as they occur in a typical eukaryotic gene.
The results will demonstrate to you that finding such a gene in a
short random DNA sequence is very easy. In fact it will show that
almost any gene that you query for can be found within the same,
comparatively very short random DNA sequence. The search
engine provides easy statistics and some visual graphics, easy to
understand. Due to computational limitations, the search engine
uses relatively short "exons" of 10-nt or less, but the results for
larger exons would differ only in scale. Also, each 10 nt invariant
DNA sequence is equivalent to an exon sequence of 200
nucleotides with codon degeneracy and amino acid degeneracy
incorporated into it. Complete instructions and explanations
are provided on the web site.
I am sure that this will provide a ground for further discussion on
the origin of the structure of genes that directly pertain to the
origin of life and organisms. I invite you to use this program, and
to analyze the extremely high probability of the occurrence of split
genes in random primordial DNA material, as opposed to the
extreme improbability of contiguous prokaryote-like genes.
The web site that contains the exon search engine:
http://www.mattox.com/genome/exons.html
If you would like further information and analysis as to "Why
are split genes easier to find?" please look at:
http://www.fullfeed.com/genome/ez2split.html
Thank you very much,
Periannan Senapathy
