PREPRINT ANNOUNCEMENT
The following paper is now available by electronic mail:
"How Adaptive Antibodies Facilitate the Evolution of Natural Antibodies"
Russell W. Anderson
(In press: Immunology and Cell Biology, 1996)
ABSTRACT:
I show how Ig specificities, randomly generated in conventional B cells,
can come to be expressed in the genetically-determinate B1 population.
Thus the adaptive antibody population facilitates the evolution of the
natural antibody repertoire, analogous to the Baldwin effect in the
evolution of instinct. I discuss the evolution of these two populations
under both the ``proximal usage" and ``preferential expression" hypotheses
of biased Ig gene segment usage. This process is independent of theories
of B1 function.
KEY WORDS: Baldwin effect; natural antibodies; learning; evolution;
CD5; Ly-1; proximal usage hypothesis
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For a postscript version or hardcopy, please send inquiries to
the author (email requests preferred):
Russell Wayne Anderson
Viral and Rickettsial Disease Laboratory
California Department of Health Services
2151 Berkeley Way
Berkeley, CA 94704
FAX (510) 848-1576
rwa at milo.berkeley.edu
