We have just made available a preliminary version of FLUCTUATE, a new
program in the LAMARC package. FLUCTUATE uses Metropolis-Hastings
sampling to estimate Theta (4Ne\mu) and exponential growth rate based
on samples of nucleotide sequences from a population: it is an extension
of our previous program COALESCE (which estimated only Theta and assumed
constant population size).
The program is written in C and should run on most machines, though it
is fairly space and time intensive. We've run it successfully on
workstations, fast PCs (486+) and PowerMacs. Currently only source code
is available.
The LAMARC package is available by anonymous ftp:
evolution.genetics.washington.edu, directory /pub/lamarc
or via the WWW at:
http://evolution.genetics.washington.edu/lamarc.html
The README file contains instructions for fetching and unpacking the
programs. We do not have the resources to mail diskettes.
Please send all queries and bug reports to:
Mary Kuhner mkkuhner at genetics.washington.edu
Felsenstein Lab
Department of Genetics
University of Washington
Box 35-7360
Seattle, WA 98195-7360
