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The key enzyme in vitamin C synthesis has been transformed to a pseudogene in humans. Reference: Nishikimi, M. and Yagi, K. (1991). Molecular basis for deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis. Am. J. Clin. Nutr. 54: 1203S-1208S. Ossi Turunen