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DATA BASE?: STE2 & STE3: yeast & humans.

Song Tan tan at mol.biol.ethz.ch
Mon Mar 18 10:38:54 EST 1996

In article
<Pine.ULT.3.91.960314175949.13504E-100000-100000 at essex.UCHSC.edu>, Teresa
Binstock <binstoct at essex.UCHSC.edu> wrote:

> On Thu, 14 Mar 1996, Teresa Binstock wrote:
> > QUESTION about data base, if any:
> > 
> > In one study findable via OVID search of Medline, STE2 and STE3 are 
> > described as occurring in the human thymic epithelium. Otherwise, all the 
> > other STE2 and STE3 studies refer to cell-surface receptors occurring in 
> > Saccharomyces Cerevisiae. Many S. Cerevisiae genes and molecules have 
> > homologues in mammals including humans. In fact, some human molecules 
> > function in yeast and vice versa.
> >       I would like to "pin-down" whether or not the human STE2 and STE3 
> > molecules reported by Patel et al are homologous to S. Cerevisiae 
> > molecules with the same nomenclature. 
> > 
> > au: Patel et al
> > so: Journal of Clinical Immunology 15.2.80-92 1995
> > ti: Characterization of human thymic epithelial cell surface antigens:
> >        phenotypic similarity of thymic epithelial cells to epidermal 
> >           keratinocytes.

I find Entrez <http://atlas.nlm.nih.gov:5700/Entrez/index.html> to be the
best tool for tracking down sequences.  However, I didn't find any
non-yeast STE2 or STE3 sequences in the GenBank database that Entrez uses,
nor any relevant epithelial sequences from authors named Patel.   Since I
don't have access to the article you cited, I wasn't able to figure out if
the authors published the sequences of the human STE2 and STE3 genes.  If
they did, it would be easy to compare them against the yeast STE2 and STE3
genes.  If they didn't publish any sequence, I'm not sure you will find
any other publicly available databases that might answer whether the human
and yeast genes are related. 

Hope this helps.

Song Tan
Institute for Molecular Biology and Biophysics
ETH-Honggerberg (Swiss Federal Institute of Technology)
8093 Zurich, Switzerland
email:  tan at mol.bio.ethz.ch

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