Physiologic Application of Molecular Biology

David Stepp dstepp at post.its.mcw.edu
Tue Nov 5 19:38:08 EST 1996

Many of us spend our days (and nights!) cloning, expressing and/or
knocking out genes that interest us.  Often times, however, we are too 
deep in the trees and lose sight of what our gene's function is in the 
context of a whole animal or even at the organ level.  I would be 
interested to know what level of enthusiasm there is out there for 
studying the physiology of your favorite gene.  If you are overexpressing 
a transcription factor that regulates cardiac gene expression, for 
example, what effect does this have on cardiac performance, blood 
pressure etc.? 

Granting agencies are asking for more than molecular biology these days;
they want relevance to a physiological or pathophysiological process. 
Within this context, would you be interested in learning physiology 
techniques (blood pressure measurements, cardiac and smooth contractility,
shear stress, electrophysiology etc) in a 2-3 week course as a means of
broadening your knowledge base and enhancing your experimental research??
Please forward your thoughts and comments to jmiano at post.its.mcw.edu.
Thanks in advance!

Joe Miano & David W. Stepp

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