Physiologic Application of Molecular Biology

Leo Bellew bellew at ix.netcom.com
Wed Nov 6 21:52:47 EST 1996

I have been the architect or chief engineer on many high-tech computer
software projects over the last 30 years where we have developed
computer models of reality in many different situations utilizing
engineering devices borrowed from areas such as artificial language
and automata theory. I am very interested in the potential for
utilizing these technologies in mapping the human genome to
physiological function. In your note, you seem to imply that the
relationships are known, at least in respect to the physiology
techniques the course would be devoted to. Can you tell me if the
problem of relating the human genome to physiological function is
largely solved, and what formal mental, mathematical or simulative
models provide the loci for that solution.

Leo Bellew

On 5 Nov 1996 16:38:08 -0800, David Stepp <dstepp at post.its.mcw.edu>

>Many of us spend our days (and nights!) cloning, expressing and/or
>knocking out genes that interest us.  Often times, however, we are too 
>deep in the trees and lose sight of what our gene's function is in the 
>context of a whole animal or even at the organ level.  I would be 
>interested to know what level of enthusiasm there is out there for 
>studying the physiology of your favorite gene.  If you are overexpressing 
>a transcription factor that regulates cardiac gene expression, for 
>example, what effect does this have on cardiac performance, blood 
>pressure etc.? 
>Granting agencies are asking for more than molecular biology these days;
>they want relevance to a physiological or pathophysiological process. 
>Within this context, would you be interested in learning physiology 
>techniques (blood pressure measurements, cardiac and smooth contractility,
>shear stress, electrophysiology etc) in a 2-3 week course as a means of
>broadening your knowledge base and enhancing your experimental research??
>Please forward your thoughts and comments to jmiano at post.its.mcw.edu.
>Thanks in advance!
>Joe Miano & David W. Stepp

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