Jonathan F. Wendel wrote:
> =
> A paper was recently published in which it was demonstrated that in
> phylogenetic analysis, a potentially misleading resolution could be
> obtained in cases where the sampled genes varied greatly in their GC
> content. The conclusion was, as I recall, that "high-GC" genes were
> spuriously linked by virtue of this compositional bias by itself. I'm
> going crazy trying to recall what this reference was..... can anyone
> help?
> =
> Thanks, Jonathan Wendel
There are a number of references for this kind of work as it is thought
to be a major problem in phylogeny reconstruction.
Methods that seek to circumvent the problem:
Galtier, N. and Gouy, M. (1995). =93Inferring phylogenies from DNA
sequences of unequal base compositions.=94 Proc. Natl. Acad. Sci. USA 92:=
11317-11321.
Lake, J. A. (1994). =93Reconstructing evolutionary trees from DNA and
protein sequences: Paralinear distances.=94 Proc. Natl. Acad. Sci. USA 91=
:1455-1459.
Lockhart, P. J., Steel, M. A., Hendy, M. D. and Penny, D. (1994).
=93Recovering evolutionary trees under a more realistic model of sequence=
evolution.=94 Mol. Biol. Evol. 11(4): 605-612.
=
and references found therein.
maybe it is a start?
James
-- =
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Dr. James O. McInerney Ph.D. Phone/Voicemail: +44 171 938 9247
Senior Scientific Officer, email:j.mcinerney at nhm.ac.uk
The Natural History Museum, =
Cromwell Road,
London SW7 5BD
UK
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Whenever I think of the past, it brings back so many memories...
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