STEALTH MICROBE CAUSES CANER
There are two basic forms of carcinogens (cancer causers):
EPIGENETIC - carcinogens that do not directly damage DNA but cause
alterations such as hormonal derangements, immunosuppression or chronic
tissue injury that in turn predisposes to cancer.
GENOTOXIC - Carcinogens that react directly with DNA or with
macromolucles that then react with DNA.
The Stealth Microbe damages tissue by its presence, and alters
hormone balance, and causes immunosuppression . The Stealth Microbe
can cause the formation of the carcinogen NMBA by cell-mediated
catalysis.
Also he Stealth Microbe secretes organic acids during carbohydrate
metabolism that can result in spontaneous nitrosation of the carcinogen
NMBA.. The Stealth Microbe is EPIGENETICALLY AND GENOTOXICALLY
CARCINOGENIC.
The rest of this document will be dedicated to medical research
that supports the statement that the stealth microbe causes
Cancer.
1980 Studies of a population with a high incidence of esophageal
carcinoma
showed that Stealth Microbe invasion was common in the esophageal
epithelium of patients with either premalignant changes or early
esophageal
carcinoma. Nitrate and Nitrite were present in high concentrations in
the
water and staple grains. This study established the ability of the
Stealth
Microbe to augment the nitrosative formation of the esophagus - specific
carcinogen benzylmethylnitrosamine (NBMA; N-nitroso-N-
methylbenzylamine). Results showed that when there were more microbes
there was also more NBMA. Spontaneous nitrosation of BMA was enhanced
under the acidic condidtions resulting from the acids secreted by the
Stealth
Microbe during Carbohydrate Metabolism. Thus, the Stealth Microbe
invasion
into the epithelium could cause local formation of NBMA by both cell-
mediated catalysis and extracellular decreases in pH.
1987 From twelve cases of precancerous lesions, 21 strains of the
Stealth
Microbe were isolated belonging to 15 different biotypes. Stealth
Microbes
obtained via biopsy were accessed for their ability to catalyze N-
nitrosobenzylmethylamine (NBMA) N-benylmethylamine and nitrite. Strains
with the higher niltrosation potential were generally isolated from
lesions with
the more advanced precancerous changes. This evidence supports the
hypothesis that the Stealth Microbe plays a causal role in the
development of
cancer, by means of endogenous nitrosamine production. The microbe is
able to secrete organic acids during carbohydrate metabolism which
decreases the local pH and this results in a considerable increase in
the
microbes production of the carcinogen NBMA.
1994 "The study was aimed at determination of possible connection
between
co-existing S.M. infection in patients with lungcarcinoma with course of
neoplastic disease and ability to achieveremission by application of
different
methods of treatment. Thestudy involved 25 patients with histologically
confirmed lung carcinoma. Their sputum and bronchial rinsings were
tested.
The tests were performed at the moment of diagnosisof the
diseases, during and after treatment. In all patients so occurrence and
type of
S.M. infections was investigated .Dynamics of S.M. infection was
measured by a scale from minimal to very severe. In about 1/3 of
patients at
the moment of diagnosisof the disease, severe or very severe infection
was
seen which was dependent of stage of the disease advancement. These
preliminary studies seem to indicate that presence of severe or very
severe S.M infection is not favorable prognostically and frequently
correlates
with a progress of neoplastic changes and worse responseto treatment."
1994 Patients with malignancies are at high risk to develop systemic
non bacterial
infections. Stealth Microbe accounts for approximately 80% of these
isolates.
The vast majority of these infections are of endogenous origin."
HOST DEFENSES AND HOW Stealth Microbe DEFEATS THEM
The skin and mucous membranes are primary
defenses
Stealth Microbe attacks and eats the skin
The mucous membranes are primary
defense
Proteinase attacks secretory IgA of mucous membranes
Gliotoxin attacks mucociliary action
Macrophages protect the respiratory
tract
Gliotoxin inhibits macrophage phagocytosis
Cell mediated immunity protects us from Stealth
Microbe
Antigen processing
Macrophage activation
(3a) Inhibited lymphokine production
(3b) Inhibited activation of T lymphocytes
Myeloperoxidase enzyme protects against
mycoses
Mannan inhibits myeloperoxidase release
Phagocytic cells are the mainstay of cellular
immunity
Stealth Microbe grows from phagocytic cells
Antiphagocytic compound
Humoral immunity: opsonization helps protect us
Proteinase reduces opsonizing activity
Humoral immunity: complement C3 role in host
defense
Proteinase degradation of complement C3
Nonimmune serum factors: transferins bind
iron
Stealth Microbe siderophores sequester iron
Lactobacillus produces potent S.M. growth
inhibitor
MORE ON Stealth Microbe PROTEINASE
Cleavage of immunoglobulins including
IgA
FC Portion of immunoglobulin g
degraded
REDUCED BACTERICIDAL ACTIVITY AGAINST ESCHERICHIA
COLI
Alpha 2 macroglobulin & alpha 1
proteinase
MORE ON MANNANS AND POLYSACCHARIDES
Multiple inhibition of proliferative
response
Mannan inhibits
lymphoproliferation
Stealth Microbe specific inhibition proliferative
response
Glycoprotein & mannan suppress
lymphoproliferation
Mannan increases hydrogen peroxide
production
Polysaccharide antigens inhibit lymphocyte
proliferation
Polysaccharide depression of cellular
function
MORE ON GLIOTOXIN
Gliotoxin present in vaginal
samples
Cultured cell growth
blocked
Gliotoxin reduces B lymphocytes
count
Irradiation increased gliotoxin
toxicity
Apoptosis
DNA fragmentation in macrophages - apoptosis
Apoptosis of mouse L929 fibroblast cells
Apoptosis in concanavalin a-stimulated t blasts
Apoptosis of T blasts and macrophages
80-95% inhibition of protein synthesis
Lymphoid organ apoptosis
Cytoskeletal structure damage & adhesion loss
Kills non-hematopoietic cells
TISSUE
DAMAGE
Extensive tissue damage
Cytoskeletal microfilament/detachment/vacuolation
Modification of microfilaments or plasma membranes
Induction of microvilli loss
Reorganization of cortical cytoplasm
Altered bile acid uptake
Afflux
Modified hormone responsiveness
(Stealth Microbe DIABETES will have much on hormones)
"Incubation of Stealth Microbe cells with human luteinizing hormone
(hLH),
human chorionic gonadotrophin(hCG) Or glucagon produced a significant
rise in cAMP total levels."
Mice treated with cortisone were susceptible to intratracheal challenge
with
10-100 x less Stealth Microbe than were untreated mice.
"Stealth Microbe also possesses enzymes that can reduce steroids at the
3-
,17-and 20-oxo-groups.
Altered morphology and plasma membrane function
Tumor-like lesions on major organs
DNA
CHANGES
Drastic DNA changes & precancerous tissue damage
Raised inositol triphosphate & DNA fragmentation
30 ng/ml prevents T & B cell DNA synthesis
DNA fragmentation of T and B cells
Genome severely damaged
Alloreactive cytotoxic T cells
DAMAGE BELOW THE GENERALIZED TOXICITY
THRESHOLD
Significant DNA damage in thymocytes at um
Glucose metabolism selectively affected
Macromolecular synthesis selectively affected
Basal rate of H2O2 production inhibited
Macrophage activity abrogated
LYMPHOPROLIFERATION
T-cell proliferation inhibition
Mitogen or interleukin induced b & t proliferation
Leukocytes as stimulator cells disabled
Depletion of murine epidermal Langerhans
Major histocompatibility complex
(nm) concentration ultrastructural damage to lc
Immune response and contact sensitivity
Increased suppressor cell activity of B-lymphocytes
Phytohemagglutinin-induced mitogen response
suppressed
Anti-sheep erythrocyte antibody response
suppressed
Anti-thy 1 antibody and complement
Not plastic-adherent or mac-1 antigen-positive
Cytotoxic T cells production failure
MACROPHAGES
Macrophage phagocytosis irreversibly inhibited
Microvilli loss and chromatin condensation
In vivo macrophage & T cell dependent mechanisms
Stealth Microbe
TOXINS
High molecular weight toxins
Glycoprotein toxins
SMtoxin
Low molecular-weight toxins
Stealth Microbe toxin investigation results
Pathogenic enzymes
Proteinase
Phospholipases
Lysophospholipase-transacylase
WHAT Stealth Microbe IS
Stealth Microbe - the most pervasive S.M. pathogen
A facultative pathogen - masquerading
marauder
Pathogenic
trickery
Pathogenesis and phenotypic
switching
Differential expression of virulence factors
Rapid alteration of phenotype
9 distinct colony phenotypes
Colony morphology
Constraints on the ___ __ _____ transition
Cellular phenotype
Patterns of gene expression
Resistance to anti-S. M. agents
Antigenicity
Stealth Microbe has amphotericin b
resistance
Pathologic states are extremely
varied
Invasive potential increases with
quantity
MORE ON WHAT Stealth Microbe DOES
Gut colony may impair cell mediated
immunity
Stealth Microbe is a cause of
immunodeficiency
Increased susceptibility to bacterial
infection
Suppressed DTH and bacterial sepsis
Elevated Stealth Microbe antigen titers & bacterial sepsis
World wide plague - often
refractory
Stealth Microbe infections are increasing in
incidence
How it isn't detected
Molecular
mimicry
Antigenic
variability
Topographical variation dependent on carbon
source
Diagnostic skin test
failure
How it is diagnosed
Successful post autopsy
diagnosis
Antemortem diagnosis is
difficult
Clinician's
uncertainty
Difficulty in differentiation - colony or
invasion
Invasive biopsy
required
Therapy by
suspicion
