signal sequence evolution

Nick Smith n.smith at bath.ac.uk
Thu Dec 4 10:27:51 EST 1997

Dear All,
        I am looking for information on signal sequence evolution.  I have a
gene showing high signal sequence divergence in mammals, and indeed evidence
of positive selection in the signal sequences (some Ka/Ks values greater
than one).  Despite this, the hydrophobicity plots of the signal peptides
are conserved (high hydrophobicicty in the middle).  Can anyone explain
this?  More generally, does anyone have any references on how well conserved
signal sequences tend to be (any data welcome, but especially mammals).
Thanks for considering this problem.

Nick Smith

Nick Smith 
Centre for Mathematical Biology
Room 0.40
School of Biology and Biochemistry
Bath University
Bath BA2 7AY
Tel: +44 (0)1225 826826 ext. 5909
Email: n.smith at bath.ac.uk
"L'exactitude n'est pas la verite "
Henri Matisse

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