IUBio

amitochondriates

Graham Clark graham.clark at lshtm.ac.uk
Thu Dec 11 11:35:04 EST 1997


Hi Andre-Denis,

I'm one of the authors responsible for some of the papers you refer to:

Entamoeba:

Clark, C.G., Roger, A.J. 1995 Proc. Natl. Acad. Sci. USA 92, 6518-6521

Trichomonas:

Bui, E.T., Bradley, P.J., Johnson, P.J. 1996 Proc. Natl. Acad. Sci. USA =09
93, 9651-9656

Horner, D.S., Hirt, R.P., Kilvington, S., Lloyd, D., Embley, T.M. 1996=20
Proc. R. Soc. Lond. B Biol. Sci. 263, 1053-1059.

Germot, A., Philippe, H., Le Guyader, H. 1996 Proc. Natl. Acad. Sci. USA
93, 14614-14617

Roger, A.J., Clark, C.G., Doolittle, W.F. 1996 Proc. Natl. Acad. Sci. USA=
=20
93, 14618-14622=20

Microsporidia:

Germot, A., Philippe, H., Le Guyader, H. 1997 Mol. Biochem. =09Parasitol.=
=20
87, 159-168

Hirt, R.P., Healy, B., Vossbrinck, C.R., Canning, E.U., Embley, T.M. =09
1997 Curr. Biol. (in press)

Giardia:

Roger, A.J., Svard, S.G., Tovar, J., Clark, C.G., Smith, M.W., Gillin,=20
F.D., Sogin, M.L. 1998 Proc. Natl. Acad. Sci. USA (In Press)

The common theme in all the papers is that the organisms encode chaperonins
(cpn60, cpn10 and/or hsp70) that have clear and specific relatedness to
the mitochondrial isoforms of these proteins. The most parsimonious=20
explanation for this is that they are descended from ancestors that had
mitochondria or harboured the symbiont that gave rise to mitochondria.

Regards,

Graham
_____________________
C. Graham Clark, Ph.D.
Department of Infectious and Tropical Diseases,
London School of Hygiene and Tropical Medicine,
Keppel Street, London WC1E 7HT, England, G.B.
Tel: ++44-171-927-2351
FAX: ++44-171-636-8739
e-mail: g.clark at lshtm.ac.uk

Please visit the Entamoeba Homepage: http://www.lshtm.ac.uk/mp/bcu/enta/
=00




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