Dear All,
I am facing problem in determining correlation between structural
similarity score and in estimate probability score (determined from
PRDF of FASTA by using 1000 suffelles). However, I am getting
very high correlation between structural similaity score and
SD score (Calculated from AMPS on 100 randomization). However,
the correlation in optimised score (PRDF )is giving quite reasonable
correlation. I am not expert may be I am not interprating PRDF output
properly. I am putting PRDF output.
#unshuffled opt score: 291; shuffled score range: 25 - 74
#opt Lambda: 0.18005 K: 0.0157; P(291) = 1.0157e-20
#For 1000 sequences, an opt score >=291 is expected 1.02e-17 times
I am taking '1.02e-17' as estimate probability and '291' as optimised
score from above output.
I would highly appriciate your help, whether I am calculating estimate
probability wrong or their is other reason, due to which I am not
getting correlation. I expect their should be high correlation between
structure similarity and estimate probability, because it is the measure
of biological significance.
Thanks
Raghava
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| Dr. G P S Raghava | Residance |
| LMB, Dept. Biochemistry | 2, Clevedon Court |
| Oxford University, South Parks| Blenheim Road, Kidlington |
| Road, Oxford, OX1 3QU, UK | Oxford, OX5 2JS, Oxford |
| Email: raghava at bioch.ox.ac.uk | UK |
| Email: raghava at biop.ox.ac.uk | Phone +44-1865-842787 |
| Phone: 275369 Fax: 275182 | |
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