Evolution of enzymes/hemoglobin

Richard Gordon gordonr at cc.UManitoba.CA
Mon Feb 7 15:19:50 EST 2000

Dear Lorenzo,
I discuss the case of hemoglobin from this point of view in:

Gordon, R. (1994). Evolution escapes rugged fitness landscapes by gene or
genome doubling: the blessing of higher dimensionality. Computers &
Chemistry  18(3), 325-332.

Best, -Dick Gordon
>I would like to know if there is any known correlation between enzymatic
>activity and evolution; i.e. if the activity of a given enzyme (its
>Kcat.)varies in the different organisms in a way that has something to
>do with their
>evolutionary distance.
> If the answer is yes, do you have any references on this subject?
> Please, reply (also) to my e-mail address, since I do not usually read
>this newsgroup.
> Thanks a lot in advance,
>	Lorenzo Stella
>Lorenzo Stella
>Stella at stc.uniroma2.it   Fax ++39-06-72594328   Tel ++39-06-72594463
>"When you have excluded the impossible, whatever remains, however
>improbable, must be the truth."      (S. Holmes)

Dr. Richard Gordon, Radiology, U. Manitoba, HSC, 820 Sherbrook Street,
Winnipeg R3A 1R9 Canada, Phone: (204) 789-3828, fax: (204) 787-2080/ Book
just out: The Hierarchical Genome & Differentiation Waves: Novel
Unification of Development, Genetics & Evolution:
http://www.wspc.com.sg/books/lifesci/2755.html, E-mail:
GordonR at cc.UManitoba.ca (Adjunct: Electrical & Computer Engineering), Exec

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