We are developing a fundamentally new formal model for
evolutionary class description (including molecular class
description).
In connection with this, (and taking into consideration that we are not
biologists by education) we would appreciate greatly information,
including references, regarding the following questions related to the
nature of mutations.
1. Since all mutations can be classified (according to Li, Molecular
evolution, p.23-34) as substitutions, recombinations (crossing-over,
gene
conversion), deletions inversions, insertions, and inversions, we
want to
know how to order them with respect to their evolutionary
emergence.
Moreover, we would like to know what are the very basic mutations
which
are responsible for the "construction" of other, more "advanced"
mutations.
2. Are there any evidence about a possibility of a "cycle" in the
evolution of a particular biomolecule.
Sincerely,
Dmitry Korkin,
University of New Brunswick
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