mtDNA haplogroups vs hypervariable region

Guy Hoelzer hoelzer at unr.edu
Tue Oct 31 11:27:31 EST 2000

In article <8tl7of$f5d$1 at mercury.hgmp.mrc.ac.uk>, APTurner at aol.com wrote:

> As I understand it, haplogroups are defined by results of a RFLP analysis and 
> hypervariable regions are reported as exact sequences. If you know where an 
> HVR-1 sequence varies from the Cambridge Reference Sequence, can you infer 
> the haplogroup? If so, how -- is there a database someplace?

If someone has used the term "haplogroups" to mean the result of RFLP
analysis, I think it is a shame.  To me this term would mean something
like a clade of haplotypes, which could be inferred from either RFLP data,
or from sequence data, reflecting any part of (or the whole) the mtDNA

Guy Hoelzer
Department of Biology
University of Nevada Reno
Reno, NV  89557

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