Thank you for your reply. The Major histocompatibility complex (MHC) is
certainly the most variable part of the genome. However, its polymorphism is
probably not appropriate to my particular interest, because it is strongly
conserved by natural selection. MHC molecules initiate an immune response to
parasites.
My interest is in the overall nuclear sequence divergence in a large number of
human individuals compared with the overall nuclear sequence divergence in a
large number of chimpanzees. Much of this divergence is probably not
essential to the survival of each species, and therefore not strongly
conserved by natural selection.
This work is probably just starting to be done now. I suppose I shall have to
be patient. I'll keep checking the current literature.
With thanks,
Andrew Gyles
In article <9eemll$m0t$1 at mercury.hgmp.mrc.ac.uk>, Bob Friedman
<friedmar at biol.sc.edu> writes:
>I did a cursory check of Genbank -- would the MHC molecule be useful?
>Bob
>>><syzygium at alphalink.com.au> > Has the Human Genome Project, and research on
>a wide range of individuals,
>> found that humans have few alleles in their nuclear chromosomes compared
>with
>> chimpanzees?
>>>> I realise that most of the chimpanzee genome has not yet been sequenced or
>> examined in a wide range of individuals, but are any comparisons available
>at
>> all?
>>>>---
>>
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