"Andrew Gyles" <syzygium at alphalink.com.au> wrote in message
news:9n0hqd$n37$1 at mercury.hgmp.mrc.ac.uk...
> An article in Am J Hum Genet 2001 Sep; 69(3): 582-589 reports
> lower-than-expected linkage disequilibrium between tightly linked markers
>> The authors suggest that the explanation is that "gene conversion
> the apparent rate of recombination between nearby loci".
>> Would not gene conversion on a large scale also reduce the sequence
> variation in the human population? As I understand the mechanism, when a
> gene is converted an allele is eliminated, so:
>> "widespread gene conversion = widespread allele loss".
>> Andrew Gyles
>A geneticist has kindly pointed out that gene conversion is not likely to
result in lower sequence variation unless the gene conversion is biased.
I would therefore be grateful for any reference to an evaluation of biased
gene conversion in any genome.