THe various protein databases do clustering of genes.
You might want to use the number of species or gene copies in a gene cluster
as a measure of convervation. E.g. Uniprot's UniRef data set.
http://www.uniprot.org/uniref/?query=histone&sort=score
(max 5,345 genes at 50% identity)
versus
http://www.uniprot.org/uniref/?query=obp&sort=score
(max 23 genes at 50% id)
-- Don
On 2010-01-27, Sidney Cambridge <cambridge from ana.uni-heidelberg.de> wrote:
>> Dear all,
>> I hope my question is not too trivial....
> I am looking for a quantitative measure of the degree of genetic
> conservation - basically attaching a high value to highly conserved
> genes such as histones and low values to genes that are not very
> conserved. Ideally there would be a database for all genes of the
> mouse or human genome with a 'conservation' value for each gene.
>> Does something like this exist ?
>> Thank you very much in advance !
>> Best,
> Sidney
