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Charlie Bell charlie.bell at cbr.for.csiro.au
Sun Apr 2 18:37:29 EST 1995


>
>Nobody doing molecular phylogeny anymore?
>
>Here's a piece of food for thought:
>Consider having hit Joe's Zone due to a few highly deviant substitution
>rates on some lineages/taxa.
>How do we determine how stable these groupings are/are not.
>I would argue that bootstrapping is irellevant here because
>bootstrapping whacked out data will give you whacked out
>pseudoreplicates.
>That is, in so far as bootstrapping claims to better "get-at" the 
>underlying distribution, if that underlying distribution
>suffers from some systematic error so will the estimation(s) made by
>bootstrapping.
>
>Mark
>
My first thought is to collect more data.
Whether you use bootsrapping or any other method for error or reliability
estimates, the results can only be as good as the data they are derived
from. If your sample is not a good representation of the true population
then you have a problem that statistics cannot overcome. 

******************************************************
Charlie Bell              Phone 06-2818324 (International) +616-2818324
CSIRO                     Fax   06-2818312 (International) +616-2818312
Division of Forestry      E-mail charlie.bell at cbr.for.csiro.au
PO Box 4008 QVT
Canberra ACT 2600
Australia
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