In article <30c3689c at d4.niaid.pc.niaid.nih.gov>,
Graham Clark <Graham_Clark at d4.niaid.pc.niaid.nih.gov> wrote:
>Jonathan A. Eisen wrote:
>>-So I ask Mark and others out there, are there examples of significant
>-differences between rRNA genes within a single organism in eukaryotes?
>-Or, in other words, how rapid is the homogenization process, and how
>-complete is it (do all of the 1000s of rRNA genes evolve in concert?).
>>There are certainly differences within genomes and within species but
>whether one considers them 'significant' is another question. Where
>multiple rRNA gene sequences from the same organism are available there
>are almost always differences - is it real or is it artifact? Probably
>a bit of both.
Clayton, R.A., Sutton, G., Hinkle Jr., P.S., Bult, C. and
Fields, C. (1995) Intraspecific Variation in Small-Subunit
rRNA Sequences in GenBank: Why Single Sequences May Not
Adequately Represent Prokaryotic Taxa.
Int. J. Syst. Bacteriol. 45, 595-599.
This paper analyzes prokaryotic sequences but the results also apply to
eukaryotic ribosomal RNA genes.
Laurence A. Moran (Larry)