IUBio

mechanism of barbiturate

Jeffrey Silverstein jeffrey.silverstein at execnet.com
Mon Aug 30 12:05:00 EST 1993


KU>@agate.berkeley.edu>
KU>Newsgroup: bionet.neuroscience
KU>Organization: University of California, Berkeley
Barbiturates acts primarily through activation of, or allosteric action
on, the GABAA chloride complex.  A reasonable starting point sort of
review was written by Richard Olsen from UCLA and was published in the
International Anesthesiology Clinics 26:254,1988.  You also might try a
chapter on intravenous anesthetics in one of the three major anesthesia
textbooks.  Most of the information that you are interested in was
procured in similar ways to the procedure you describe.
J. Silverstein
Anesthesia-ICU Research
Bronx VAMC
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