In article <1993Jan6.180218.9721 at welchgate.welch.jhu.edu>
danj at welchgate.welch.jhu.edu (Dan Jacobson) writes:
>pmuniyap at magnus.acs.ohio-state.edu writes:
>> > Is there any evidence to support that the neuro-enzyme
> >Acetylcholinesterase (AChE) is associated with any diseases? For eg,
> >Alzheimers Disease. I have just started a research project involving
AChE and
> >I am curious of the potential for continued research in this area.
>> This is a good question to ask the database known as ONLINE MENDELIAN
> INHERITANCE IN MAN (OMIM). There are several ways that you can access
> this database. Probably the easiest is by Gopher or Wais. If you have
> gopher, point it at merlot.welch.jhu.edu (port 70). Go to the
>> 13. Search Databases at Welchlab (Cloning Vectors, Euk. Promoters,
NRL_3D, OMIM)
>> directory and select the following search -
>> --> 5. OMIM - Online Mendelian Inheritance Man <?>
>> A search with the word Acetylcholinesterase returns the following
entries:
>> --> 1. *100740 ACETYLCHOLINESTERASE [ACETYLCHOLINE ACETYLHYDROLASE;
ACHE].
> 2. 100680 ACETYLCHOLINESTERASE EXPRESSION [ACEE; REGULATOR
OFACETYLC.
> 3. 254190 MYASTHENIA, CONGENITAL, REFRACTORY TO
ACETYLCHOLINESTERASE.
> 4. #112100 BLOOD GROUP--Yt SYSTEM [YT; CARTWRIGHT].
> 5. *177400 PSEUDOCHOLINESTERASE, E(1) [CHE1;
BUTYRYLCHOLINESTERASE;B.
> 6. *254210 MYASTHENIA GRAVIS, FAMILIAL INFANTILE [FIMG;
MYASTHENIA,C.
> 7. *114836 CARBOXYLESTERASE, LIVER.
> 8. *118503 CHOLINERGIC RECEPTOR, NEURONAL NICOTINIC, ALPHA
POLYPEPTI.
> 9. *178630 PULMONARY SURFACTANT APOPROTEIN PSP-A [PSAP;
SURFACTANT-A.
>> Now you can select the desired entries, read them and save them on your
machine
> if you'd like.
>> If you'd rather connect by Wais the source is as follows:
>> (:source
> :version 3
> :ip-address "128.220.59.10"
> :ip-name "welchlab.welch.jhu.edu"
> :tcp-port 210
> :database-name "omim"
> :cost 0.00
> :cost-unit :free
> :maintainer "francois at welch.jhu.edu"
> :subjects "science genetics medicine chromosomes biology mendelian"
> )
>>>> Best of luck,
>> Dan Jacobson
>>danj at welchgate.welch.jhu.edu
Most of these references refer to AChesterase in the peripheral nervous
system, not the CNS.
Andrew Penn
