In article <HURH-180193202121 at 131.225.123.13> HURH at FNAL.FNAL.GOV (Patrick Hurh) writes:
>Newsgroups: bionet.neuroscience
>Path: bme.ri.ccf.org!usenet.ins.cwru.edu!magnus.acs.ohio-state.edu!zaphod.mps.ohio-state.edu!sdd.hp.com!spool.mu.edu!uwm.edu!linac!newsaintmail
>From: HURH at FNAL.FNAL.GOV (Patrick Hurh)
>Subject: basic info on endorpins wanted
>Message-ID: <HURH-180193202121 at 131.225.123.13>
>Followup-To: bionet.neuroscience
>Sender: daemon at linac.fnal.gov (The Background Man)
>Nntp-Posting-Host: 131.225.123.13
>Organization: Fermi Lab
>Date: Tue, 19 Jan 1993 02:44:03 GMT
>Lines: 38
>Hope this isn't too stupid (or broad) of a question, but I'd like to find
>some basic info on endorphin (or enkephalin) production and effects (proven
>or deduced) on behavior. I'm looking for a basic book or two that can
>explain what has so far proven to be a confusing subject.
>>I'm a mechanical engineer so my neuroscience reading level is quite low,
>but I'd be willing to sift through technical jargon to find out more. I'm
>mainly interested in these endogenous (sp?) opiates because I want to
>incorporate them as plot devices in several short sci-fi stories I'm trying
>to write. I'm _not_ trying to write a treatsie or a layman's term article.
> I want the real stuff so I can extrapolate the info into a believable (for
>the average reader) future.
>>In particular:
>>1) Where are the endorphin/enkephalin precursors produced (primarily)?
>Are they ever produced in glands which are not endogenous? Does the blood
>brain barrier block/filter the flow of endorphins from the blood system to
>the brain?
>>2) What would result from the direct introduction of endorphins or
>endorphin precursors (I'm thinking of beta-lipotropin) into the
>hippocampus? into the hypothallmus (SP?) ?
>>3) Are endorphins/enkephalins readily syntesized? IF not, why not?
>>4) Am I even _referring_ to the proper neurotransmitter chemicals?
>>I don't expect any specific answers from netters but would appreciate any
>references which may be available. I've tried using WAIStation to search
>for papers but I can't seem to find the right source file to search (any
>ideas?).
>>PS Even if no-one responds on this subject could one or two people E-Mail
>me that they saw this here? I've started using a new newsreader and want
>to make sure the distribution is set up correctly.
>>Thanks in advance, Patrick HURH at FNAL.FNAL.GOV
Try some of these references....Doug Knowles....
1
UI - 91197644
AU - Pleuvry BJ
TI - Opioid receptors and their ligands: natural and unnatural [see comments].
SO - British Journal of Anaesthesia 1991 Mar;66(3):370-80
2
UI - 92270496
AU - Olson GA
AU - Olson RD
AU - Kastin AJ
TI - Endogenous opiates: 1990.
SO - Peptides 1991 Nov-Dec;12(6):1407-32
3
UI - 91029554
AU - Bodnar RJ
TI - Effects of opioid peptides on peripheral stimulation and "stress"-induced
analgesia in animals.
SO - Critical Reviews In Neurobiology 1990;6(1):39-49
4
UI - 91029552
AU - Ramabadran K
AU - Bansinath M
TI - The role of endogenous opioid peptides in the regulation of pain.
SO - Critical Reviews In Neurobiology 1990;6(1):13-32
5
UI - 91029551
AU - Szekely JI
TI - Opioid peptides and stress.
SO - Critical Reviews In Neurobiology 1990;6(1):1-12
6
UI - 91204556
AU - Olson GA
AU - Olson RD
AU - Kastin AJ
TI - Endogenous opiates: 1989.
SO - Peptides 1990 Nov-Dec;11(6):1277-304
7
UI - 91076290
AU - Carr DB
AU - Lipkowski AW
TI - Neuropeptides and pain.
SO - Agressologie 1990 Apr;31(4):173-7
8
UI - 91042964
AU - Bhargava HN
TI - Opioid peptides, receptors, and immune function.
SO - NIDA Research Monograph 1990;96:220-33
9
UI - 90320813
AU - Banks WA
AU - Kastin AJ
TI - Peptide transport systems for opiates across the blood-brain barrier.
SO - American Journal of Physiology 1990 Jul;259(1 Pt 1):E1-10
10
UI - 90202183
AU - Ramabadran K
AU - Bansinath M
TI - Glucose homeostasis and endogenous opioid peptides.
SO - International Journal of Clinical Pharmacology, Therapy, & Toxicology
1990 Mar;28(3):89-98
11
UI - 90260008
AU - Gulya K
TI - The opioid system in neurologic and psychiatric disorders and in their
experimental models.
SO - Pharmacology & Therapeutics 1990;46(3):395-428
12
UI - 89315376
AU - Olson GA
AU - Olson RD
AU - Kastin AJ
TI - Endogenous opiates: 1987.
SO - Peptides 1989 Jan-Feb;10(1):205-36
13
UI - 90116433
AU - Stengaard-Pedersen K
TI - Opioid peptides and receptors. Localization, interactions and
relationships to other molecules in the rodent brain, especially the
hippocampal formation.
SO - Progress In Histochemistry & Cytochemistry 1989;20(3):1-119
14
UI - 90160050
AU - Olson GA
AU - Olson RD
AU - Kastin AJ
TI - Endogenous opiates: 1988.
SO - Peptides 1989 Nov-Dec;10(6):1253-80
15
UI - 88250972
AU - Smith AP
AU - Lee NM
TI - Pharmacology of dynorphin.
SO - Annual Review of Pharmacology & Toxicology 1988;28:123-40
16
UI - 89124763
AU - Grossman A
TI - Opioids and stress in man.
SO - Journal of Endocrinology 1988 Dec;119(3):377-81
17
UI - 89265680
AU - Naber D
TI - Clinical relevance of endorphins in psychiatry.
SO - Progress In Neuro-Psychopharmacology & Biological Psychiatry 1988;
12 Suppl:S119-35
W. Douglas Knowles, Ph.D. E-mail: knowled at ccsmtp.ri.ccf.org
Department of Neurosciences voice: (216) 444-3870
Cleveland Clinic Foundation FAX: (216) 444-7927
9500 Euclid Avenue
Cleveland, OH 44195 USA other: hey, you!
quote: "We need not all give our whole time to the currently more glamorous
"molecular biology"; it will doubtless come soon enough." I.H. Page 1962
