basic info on endorpins wanted

Doug Knowles knowled at ccsmtp.ri.ccf.org
Tue Jan 19 13:09:47 EST 1993

In article <HURH-180193202121 at> HURH at FNAL.FNAL.GOV (Patrick Hurh) writes:
>Newsgroups: bionet.neuroscience
>Path: bme.ri.ccf.org!usenet.ins.cwru.edu!magnus.acs.ohio-state.edu!zaphod.mps.ohio-state.edu!sdd.hp.com!spool.mu.edu!uwm.edu!linac!newsaintmail
>From: HURH at FNAL.FNAL.GOV (Patrick Hurh)
>Subject: basic info on endorpins wanted
>Message-ID: <HURH-180193202121 at>
>Followup-To: bionet.neuroscience
>Sender: daemon at linac.fnal.gov (The Background Man)
>Organization: Fermi Lab
>Date: Tue, 19 Jan 1993 02:44:03 GMT
>Lines: 38
>Hope this isn't too stupid (or broad) of a question, but I'd like to find
>some basic info on endorphin (or enkephalin) production and effects (proven
>or deduced) on behavior.  I'm looking for a basic book or two that can
>explain what has so far proven to be a confusing subject.
>I'm a mechanical engineer so my neuroscience reading level is quite low,
>but I'd be willing to sift through technical jargon to find out more.  I'm
>mainly interested in these endogenous (sp?) opiates because I want to
>incorporate them as plot devices in several short sci-fi stories I'm trying
>to write.  I'm _not_ trying to write a treatsie or a layman's term article.
> I want the real stuff so I can extrapolate the info into a believable (for
>the average reader) future.
>In particular:
>1)  Where are the endorphin/enkephalin precursors produced (primarily)? 
>Are they ever produced in glands which are not endogenous?  Does the blood
>brain barrier block/filter the flow of endorphins from the blood system to
>the brain?
>2)  What would result from the direct introduction of endorphins or
>endorphin precursors (I'm thinking of beta-lipotropin) into the
>hippocampus? into the hypothallmus (SP?) ?
>3)  Are endorphins/enkephalins readily syntesized?  IF not, why not?
>4)  Am I even _referring_ to the proper neurotransmitter chemicals?
>I don't expect any specific answers from netters but would appreciate any
>references which may be available.  I've tried using WAIStation to search
>for papers but I can't seem to find the right source file to search (any
>PS Even if no-one responds on this subject could one or two people E-Mail
>me that they saw this here?  I've started using a new newsreader and want
>to make sure the distribution is set up correctly.
>Thanks in advance,       Patrick                 HURH at FNAL.FNAL.GOV

Try some of these references....Doug Knowles....

UI  - 91197644
AU  - Pleuvry BJ
TI  - Opioid receptors and their ligands: natural and unnatural [see comments].
SO  - British Journal of Anaesthesia 1991 Mar;66(3):370-80

UI  - 92270496
AU  - Olson GA
AU  - Olson RD
AU  - Kastin AJ
TI  - Endogenous opiates: 1990.
SO  - Peptides 1991 Nov-Dec;12(6):1407-32

UI  - 91029554
AU  - Bodnar RJ
TI  - Effects of opioid peptides on peripheral stimulation and "stress"-induced
      analgesia in animals.
SO  - Critical Reviews In Neurobiology 1990;6(1):39-49

UI  - 91029552
AU  - Ramabadran K
AU  - Bansinath M
TI  - The role of endogenous opioid peptides in the regulation of pain.
SO  - Critical Reviews In Neurobiology 1990;6(1):13-32

UI  - 91029551
AU  - Szekely JI
TI  - Opioid peptides and stress.
SO  - Critical Reviews In Neurobiology 1990;6(1):1-12

UI  - 91204556
AU  - Olson GA
AU  - Olson RD
AU  - Kastin AJ
TI  - Endogenous opiates: 1989.
SO  - Peptides 1990 Nov-Dec;11(6):1277-304

UI  - 91076290
AU  - Carr DB
AU  - Lipkowski AW
TI  - Neuropeptides and pain.
SO  - Agressologie 1990 Apr;31(4):173-7

UI  - 91042964
AU  - Bhargava HN
TI  - Opioid peptides, receptors, and immune function.
SO  - NIDA Research Monograph 1990;96:220-33

UI  - 90320813
AU  - Banks WA
AU  - Kastin AJ
TI  - Peptide transport systems for opiates across the blood-brain barrier.
SO  - American Journal of Physiology 1990 Jul;259(1 Pt 1):E1-10

UI  - 90202183
AU  - Ramabadran K
AU  - Bansinath M
TI  - Glucose homeostasis and endogenous opioid peptides.
SO  - International Journal of Clinical Pharmacology, Therapy, & Toxicology 
      1990 Mar;28(3):89-98

UI  - 90260008
AU  - Gulya K
TI  - The opioid system in neurologic and psychiatric disorders and in their
      experimental models.
SO  - Pharmacology & Therapeutics 1990;46(3):395-428

UI  - 89315376
AU  - Olson GA
AU  - Olson RD
AU  - Kastin AJ
TI  - Endogenous opiates: 1987.
SO  - Peptides 1989 Jan-Feb;10(1):205-36

UI  - 90116433
AU  - Stengaard-Pedersen K
TI  - Opioid peptides and receptors. Localization, interactions and
      relationships to other molecules in the rodent brain, especially the
      hippocampal formation.
SO  - Progress In Histochemistry & Cytochemistry 1989;20(3):1-119

UI  - 90160050
AU  - Olson GA
AU  - Olson RD
AU  - Kastin AJ
TI  - Endogenous opiates: 1988.
SO  - Peptides 1989 Nov-Dec;10(6):1253-80

UI  - 88250972
AU  - Smith AP
AU  - Lee NM
TI  - Pharmacology of dynorphin.
SO  - Annual Review of Pharmacology & Toxicology 1988;28:123-40

UI  - 89124763
AU  - Grossman A
TI  - Opioids and stress in man.
SO  - Journal of Endocrinology 1988 Dec;119(3):377-81

UI  - 89265680
AU  - Naber D
TI  - Clinical relevance of endorphins in psychiatry.
SO  - Progress In Neuro-Psychopharmacology & Biological Psychiatry 1988;
      12 Suppl:S119-35

W. Douglas Knowles, Ph.D.            E-mail: knowled at ccsmtp.ri.ccf.org
Department of Neurosciences          voice:  (216) 444-3870
Cleveland Clinic Foundation          FAX:    (216) 444-7927
9500 Euclid Avenue                   
Cleveland, OH 44195 USA              other:   hey, you!
quote: "We need not all give our whole time to the currently more glamorous
"molecular biology"; it will doubtless come soon enough."  I.H. Page 1962

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