In article <93Mar24.231255.37188 at acs.ucalgary.ca> jdbecker at acs.ucalgary.ca (Jason Dean Becker) writes:
>Is anyone else out there working with the noradrenergic
>neurotoxin DSP-4? I am VERY interested in discussing use of this
>compound with you.
>
A gopher search of all researches funded by NIH found the following hit
for DSP-4:
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PRINCIPAL INVESTIGATOR
DE SOUZA, E B
ARC, NIDA
PERFORMING ORGANIZATION:
TITLE Neurotoxicity of selected drugs to monoamine neurons in brain
ABSTRACT:
The effects of selected drugs on monoamine neurons in brain has been
examined. Fenfluramine, in high doses, has been found to decrease
monoamine uptake sites in rat brain suggesting a neurotoxic effect at
these high doses. The pharmacokinetics, and regional specificity as well
as the time course of these effects have been examined. Also, DSP-4 h as
been shown to have different effects on norepinephrine uptake in the
cerebral cortex versus the hypothalamus. These studies provide evidence
for a heterogeneity of norepinephrine sites.
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Instructions on doing this search were posted yesterday to bionet.general
- briefly - point your gopher client at merlot.welch.jhu.edu,
choose the --> 14. Searching For Biologists/ directory, and then
select:
--> 2. Search for All Researchers funded by NIH <?>.
Further searches for related areas of interest may find more people to
contact.
Best of luck,
Dan Jacobson
danj at welchgate.welch.jhu.edu
