In article <93Mar24.231255.37188 at acs.ucalgary.ca> jdbecker at acs.ucalgary.ca (Jason Dean Becker) writes:
>Is anyone else out there working with the noradrenergic
>neurotoxin DSP-4? I am VERY interested in discussing use of this
>compound with you.
A gopher search of all researches funded by NIH found the following hit
DE SOUZA, E B
TITLE Neurotoxicity of selected drugs to monoamine neurons in brain
The effects of selected drugs on monoamine neurons in brain has been
examined. Fenfluramine, in high doses, has been found to decrease
monoamine uptake sites in rat brain suggesting a neurotoxic effect at
these high doses. The pharmacokinetics, and regional specificity as well
as the time course of these effects have been examined. Also, DSP-4 h as
been shown to have different effects on norepinephrine uptake in the
cerebral cortex versus the hypothalamus. These studies provide evidence
for a heterogeneity of norepinephrine sites.
Instructions on doing this search were posted yesterday to bionet.general
- briefly - point your gopher client at merlot.welch.jhu.edu,
choose the --> 14. Searching For Biologists/ directory, and then
--> 2. Search for All Researchers funded by NIH <?>.
Further searches for related areas of interest may find more people to
Best of luck,
danj at welchgate.welch.jhu.edu