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Neurobiology of Fear

matt spitzer mwspitze at uci.edu
Mon Dec 12 16:18:43 EST 1994


In article <3c9tir$s8k at charm.magnus.acs.ohio-state.edu>,
plaudrup at magnus.acs.ohio-state.edu (Peter Laudrup) wrote:

> And Matt Spitzer answers:
> Benzodiazepines work by potentiating GABAergic synaptic transmission, so I
> suppose the "endogenous benzodiazepine" would be GABA.
> 
> I agree about the effects of benzodiazepins on the GABA receptor complex, a 
> potentiation. However, I strongly hesitate to consider GABA as "endogenous
> benzodiazepine".
> 

Fair enough.  Just out of curiosity, are there any candidates for an
endogenous ligand that might act at the benzodiazepine site to regulate the
GABA receptor?



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