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glutamate -- NMDA

TAO T. WANG toddwang at welchlink.welch.jhu.edu
Wed Dec 14 13:08:35 EST 1994

Hi, everyone,
it's me again who is doing some modeling work about NO transmission.


1. If increasing the concentration of glutamate, what will be caused 
in its receptor channel (NMDA or non-NMDA) current. 

For example: 
2-fold increase in the concentration of glutamate release will cause:

(a) 2-fold increase in the current of *single* receptor channel? 
(b) 2-fold increase in the number of open channel? 
(c) some other changes?
2. If the concentration of glutamate has a fast change, for example,
the glutamate concentration is changed only for 2 ms, or even less,
this kind of transient change will also cause some change in its receptor
channel current?

Any reply will be highly appreciated !

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