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glutamate -- NMDA

TAO T. WANG toddwang at welchlink.welch.jhu.edu
Wed Dec 14 13:08:35 EST 1994


Hi, everyone,
it's me again who is doing some modeling work about NO transmission.

questions: 

1. If increasing the concentration of glutamate, what will be caused 
in its receptor channel (NMDA or non-NMDA) current. 

For example: 
2-fold increase in the concentration of glutamate release will cause:

(a) 2-fold increase in the current of *single* receptor channel? 
                   or
(b) 2-fold increase in the number of open channel? 
                   or 
(c) some other changes?
 
2. If the concentration of glutamate has a fast change, for example,
the glutamate concentration is changed only for 2 ms, or even less,
this kind of transient change will also cause some change in its receptor
channel current?

Any reply will be highly appreciated !
  



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