In article <2vqplp$p4a at search01.news.aol.com> D Blissard, dblissard at aol.com
writes:
> Does anyone know if it is possible to block action potentials in a nerve
> bundle electrically for minutes at a time without damage to the nerves.
> And if it is possible how would this best be accomplished ( constant
> current, voltage clamp, or other).
>> Any information, references, advice, or comments would be greatly
> appreciated.
See work done by Mortimer and Fang around 1990/1. I don't have the exact refs
handy, but you should be able to get them using MedLine Express, I would think.
They used asymmetric cuff electrodes and quasi-trapezoidal waveforms to
propogate antidromic APs to effect blockade.
jon
----------------------------------------------------------------------
Jonathan Jacobs jxj24 at po.cwru.edu <--
jacobs at cwbiol2.biol.cwru.edu
Department of Biomedical Engineering
Case Western Reserve University Rm. 300, Biology Building
Cleveland, OH 44106-7080 216.368.3574 (lab)
