Postdoctoral Positions Available

Gerry S. Oxford gsox at med.unc.edu
Fri Jul 15 08:13:42 EST 1994


        Signal Transduction Mechanisms Linking G-Protein
               Coupled Receptors to Ion Channels

Dopamine receptors of the D2 class couple through G-proteins to
the activation of inwardly rectifying potassium ion channels in
pituitary prolactin secreting cells and neurons of the striatum
and substantia nigra.  Two postdoctoral research positions are
available immediately in the laboratory of Dr. Gerry Oxford to
investigate the molecular mechanisms coupling dopamine receptors
to ion channels in both pituitary and neuronal cells.  Our approach
involves combining patch clamp electrophysiology of cultured
cells with manipulation of cloned receptors and channels using the
techniques of molecular biology to reveal the specificity and
nature of the signal transduction process. In addition, we employ
novel immunological methods of quantifying the secretion of
peptides from single cells to monitor the physiological
consequences of normal and altered receptor-channel coupling.

Candidates should have a Ph.D. and experience in standard methods
of modern molecular biology and/or experience in patch clamp
recording methods.  Experience with protein expression in
eukaryotic cells is particularly desirable.  Salaries are
competitive and the funding sources secure for the next several
years.  The Research Triangle area of North Carolina affords
a wonderful environment for both science and living.

Individuals interested in either of these positions should
send a letter describing research interests, a recent curriculum
vita, and names and addresses of three references to:

Gerry S. Oxford, Ph.D.
Department of Physiology
University of North Carolina
Box 7545
Chapel Hill, NC  27599
Phone:	(919)-962-7157
FAX:	(919)-966-6927
email:	gsox at med.unc.edu

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