Dynamics of Mammalian Neurons

William Calvin wcalvin at u.washington.edu
Sat Jul 30 17:50:18 EST 1994

herwin at mason1.gmu.edu (HARRY R. ERWIN) writes:

>I would expect the sigmoid relationship at the population level to be
>robust for almost any reasonable model of the neuron. The assymetry is
One caution, and this from someone who used to emphasize f-I curves (the 
individual cell's version of that sigmoid):  in cerebral cortex, there is 
a significant possibility that a relatively few inputs are producing 
AND-gate behavior.  I say this from Softky & Koch's statistical analysis 
(Neural COmputation 1992, J. Neurophysiol. 1993) of single neuron 
firing.  The sigmoid may be more appropriate to motorneuron pools where 
individual inputs are insignificant, where only hundreds at a time manage 
to get a repetitive output going.
    William H. Calvin  WCalvin at U.Washington.edu

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