I've heard that bacterial flagella have protons going through the hole
down the middle, so why not microtubules? Will ask for refs if you can't
Best regards, -Dick Gordon, U. Manitoba[Nov12,94]
On 12 Nov 1994, Harry Erwin wrote:
> I believe it was Peter Mitchell who worked out the mechanism of
> oxidative phosphorylation. It involves a proton conductance through a
> membrane, which overcomes the problems with the charge on the proton.
> The reason I bring this up is that there is a problem with neural
> spines--the spine neck is quite narrow, and does not allow ionic flow
> between the spine and the dendrite.
>> However, my taking a course from Harold Morowitz on metabolism begins to
> provide some insight here. He keeps emphasizing the importance of static
> cell structure to how the cell operates. (He's taken metazoans down
> nearly to absolute zero and then revived them--which you could not do if
> persistent dynamics were necessary to life.) The problem with the spine
> neck would go away if there were some sort of biological structure that
> supported the necessary ion flow. I.e., ion wires through the neck...
>> Has anyone looked to see if microtubules supported ionic conductance?
> That would also start to provide some insight into their role in the
> protistan neuroskeleton. Based on structure, they might even function as
> some sort of coaxial cable.
> Harry Erwin
> Internet: herwin at gmu.edu>>