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NO and epilepsy

John Anderson in Anderson Lab anderson at CSHL.ORG
Tue Nov 22 20:55:09 EST 1994

>I recently saw a poster at the Neuroscience meeting in Miami that
>suggested that NO could act presynaptically to reduce neurotransmitter
>release, however, the molecular mechanism was not clear.  During ishemia,
>one of the major events is massive release of neurotransmitter.  Perhaps NO
>could play a positive role in reducing ishemic damage by reducing
>neurotransmitter release.  Just a thought.

This is interesting.  Last summer there was an article in Neuron
reporting that NO led to a calcium-independent _increase_ in
transmitter release.  This was 

Meffert M.K., Premack B.A., Schulman H. (1994) 
"Nitric oxide stimulates Ca2+-independent synaptic vesicle release"
Neuron 12:1235-1244.

The work was done with hippocampal synaptosomes.  Vesicle release was
measured either indirectly by a decrease in fluorescence of the dye
FM1-43, or directly by an increase in extra-synaptosomal tritiated

Can you give any more details of the poster you saw?  Who were the


John E. Anderson                                    904-448-6286 (phone)
9439 San Jose Boulevard #226                   anderson at cshl.org (email)
Jacksonville, Florida 32257                  jander at unf6.unf.edu (email)

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