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Name of endogenous PCP?

spjtcgn at ucl.ac.uk spjtcgn at ucl.ac.uk
Tue Nov 29 07:28:40 EST 1994


In article <jdbecker-241194150332 at sainsbury.psych.ucalgary.ca>, jdbecker at acs.ucalgary.ca (Jason Becker) says:
>
>Does anyone know the name of endogenous PCP (phencyclidine)? I think it was
>discovered by looking at pig brains.

"Alpha-endopsychosin" is probably the relevant stuff!:

   Contreras-PC; DiMaggio-DA; O'Donohue-TL (1985)  Evidence for an endogenous peptide
ligand and antagonist for PCP receptors. Prog-Clin-Biol-Res. 192: 495-8
"Alpha-Endopsychosin, an endogenous ligand for the phencyclidine receptor, has been
isolated from porcine brain. The endogenous ligand is a peptide and has similar actions to
PCP and is selectively distributed in the brain. A PCP analogue, Metaphit, has also been
found to be an effective PCP antagonist. This antagonist may be useful for evaluating the role
of the brain's alpha-endopsychosin system and may have a number of important clinical
uses."




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