A studentship is available (from September 1995) for research leading
to a Ph.D. in the Neurotransmission Laboratory of the Anaesthetics
Unit of the London Hospital Medical College.
Cerebral ischaemia is a major cause of permanent debility.
The objective of this project is to determine the chronology
of transmitter release events during the early phase of ischaemia
and to establish the window of therapeutic opportunity using a r
eal-time transmitter measurement method in brain slices. The N
eurotransmission laboratory has established an in vitro
method to investigate cerebral ischaemia in striatal and cortical
brain slices that eliminates the haemodynamic considerations
dependency observed in vivo and thus allows neuroprotective effects t
o be characterised independent of haemodynamic phenomena. The
intention is to establish the sequence of events that occur in
this phase and thus to elucidate mechanisms that may be amenable t
o pharmacological intervention, particularly by those agents used
in clinical anaesthesia. The project is under the supervision of
Dr Jon Stamford.
HOW TO APPLY
The successful candidate will be highly motivated and already hold,
or be expected to receive, at least an upper second in pharmacology,
physiology, biochemistry or a related discipline. Application is b
y submission of full CV and 2 letters of reference, at least one
from a member of staff of the applicants current department.
Further details from:
Mrs S. Stevens, (secretary) Anaesthetics Unit, London Hospital M
edical College, Alexandra Wing, Royal London Hospital, Whitechapel, L
ondon E1 1BB. (Tel: +44 171 377 7725).Or email Dr Jon Stamford
(j.stamford at lhmc.ac.uk)
31st July 1995