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Lithium effect on the brain

Mr R.B. Ostler rbostler at chcmga
Tue Jul 4 12:21:21 EST 1995

On Fri, 30 Jun 1995, Tremblay Guy wrote:

> Hello everybody
> I am currently working on interaction between nucleic acids and lithium. Could
> someone explain how the Lithium is said to fight against manic depression? I
> know of one hypothesis stating that it stabilizes phospholipids present in
> neuron membranes. Also, it is known that it increases the quantity of
> inositol-phosphate (inhibition of inositol phosphatase???). How is this
> achieved? I'd enjoy to know more about concurrent hypothesis. Thank you very
> much and have a nice day!     8^)   
> Guy Tremblay. Universite de Montreal. Department of Biochemistry.
> tremblgu at medcn.umontreal.ca
I have heard that the lithium ion with its large solvent cage interferes
 with the Na+ and K+ channels in neurotransmission,( although I dont know 
how true this is.) > > 

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