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Graduate studentship (Neurochemistry of stroke)

Jon Stamford j.stamford at lhmc.ac.uk
Tue Jul 11 09:28:41 EST 1995

A studentship is available (from September 1995) for research 
leading to a Ph.D. in the Neurotransmission Laboratory of the 
Anaesthetics Unit.

The project

Cerebral ischaemia is a major cause of permanent debility. The 
objective of this project is to determine the chronology of 
transmitter release events during the early phase of ischaemia 
and to establish the window of therapeutic opportunity using a 
real-time transmitter measurement method in brain slices. The 
Neurotransmission laboratory has established an in vitro method 
to investigate cerebral ischaemia in striatal and cortical brain 
slices that eliminates the temperature dependency observed in 
vivo and thus allows neuroprotective effects to be characterised 
independent of haemodynamic phenomena. The intention is to establish 
the sequence of events that occur in this phase and thus to elucidate 
mechanisms that may be amenable to pharmacological intervention, p
articularly by those agents used in clinical anaesthesia. The 
project is under the supervision of Dr Jon Stamford.

The department

The Anaesthetics Unit combines clinical and fundamental research, 
conducted by both basic scientists and clinical researchers. There 
is a broad base of research interests within the department and 
strong specialisation in specific areas such as in vivo 
neurochemistry, novel muscle relaxants, and intensive care.

How to apply

The successful candidate will be highly motivated and already 
hold, or be expected to receive, at least an upper second (or overseas
equivalent) in pharmacology, physiology, biochemistry or a related d
iscipline. Application is by submission of full CV and 2 letters 
of reference, at least one from a member of staff of the 
applicant’s current department.

Further details from:

Mrs S. Stevens, (secretary) Anaesthetics Unit, London Hospital 
Medical College, Alexandra Wing, Royal London Hospital, W
hitechapel, London E1 1BB. (Tel: 0171 377 7725).Or email me at
j.stamford at lhmc.ac.uk

Closing date:

31st July 1995

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