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motor neurone disease

Lyn Frumkin lrfrum at hardy.u.washington.edu
Sun Jul 16 06:08:37 EST 1995

Andrew Ray (aray at emory.edu) wrote:
: In article <3u9dsn$36u at eden.adam.com.au>, alex at eve.adam.com.au (alex alexander) 
: writes:

: >I am a medical general practitioner in Adelaide, Australia.
: >My father in law has motor neurone disease, as did my own father.
: >Any one know of the latest in research in this topic with regards
: >to trialing this man on any possible research drugs, as his current
: >position is hopeless and he only has 2 or 3 months to live.
: >Would appreciate responses either to me or to the newsgroup.
: >Will post responses also to a specific motor-neurone group which has
: >very little traffic.
: >
: >Dr.Alex Alexander MBBS PhD(Comp Sci)
: >
: Dr. Alexander,
: I don't know what you mean by motor neurone disease (peripheral, central, MD,
: MS, etc.?), but as a Ph. D. student in neuroscience at Emory, I can tell you
: that the Neurology dept. is extensively involved in motor control, and the 
: Anatomy/Physiology depts. of the University are doing some research into 
: peripheral motor/spinal motor systems.  If they aren't specifically doing what
: you are asking for, maybe they can point you in the right direction.  Good 
: Luck, I hope you find what you need.

: Andrew Ray
: Emory Neuroscience Program
: aray at emory.ed

The term "motor neuron disease" is used synonymous with the disease  
amyotrophic lateral sclerosis [also called Lou Gehrig's disease or ALS]. As 
such, motor neuron disease ["ALS"] is both a central and peripheral 
process clinically involving progressive weakness without sensory deficits
and involving degeneration of corticospinal tracts and/or anterior horn 
cells and/or bulbar nuclei. Although I am not aware of what clinical trials are 
ongoing in Australia, there are a number of trials in the US, especially 
with brain-derived nerve growth factor [BDNGF]. The following American 
organizations may be able to help you locate trials in Australia:

The ALS Association (818-3407500)
Center for Neurologic Study (619-4555463)
Les Turner ALS Foundation (708-679-3311)
Norris ALS Research Center (415-7502398)


Lyn Frumkin, MD, PhD (neurology)

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