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Neurochemistry of Stroke research (deadline: 31/7/95)

Jon Stamford j.stamford at lhmc.ac.uk
Thu Jul 20 05:04:54 EST 1995

A studentship is available (from September 1995) for research 
leading to a Ph.D. in the Neurotransmission Laboratory of the 
Anaesthetics Unit.

The project

Cerebral ischaemia is a major cause of permanent debility. The 
objective of this project is to determine the chronology of 
transmitter release events during the early phase of ischaemia 
and to establish the window of therapeutic opportunity using a r
eal-time transmitter measurement method in brain slices. The N
eurotransmission laboratory has established an in vitro method 
to investigate cerebral ischaemia in striatal and cortical brain 
slices that eliminates the temperature dependency observed in 
vivo and thus allows neuroprotective effects to be characterised 
independent of haemodynamic phenomena. The intention is to 
establish the sequence of events that occur in this phase and 
thus to elucidate mechanisms that may be amenable to 
pharmacological intervention, particularly by those agents 
used in clinical anaesthesia. The project is under the
supervision of Dr Jon Stamford.

How to apply

The successful candidate will be highly motivated and already 
hold, or be expected to receive, at least an upper second in 
pharmacology, physiology, biochemistry or a related discipline. 
Application is by submission of full CV and 2 letters of reference, 
at least one from a member of staff of the applicant’s 
current department.

Further details from:

Mrs S. Stevens, (secretary) Anaesthetics Unit, London 
Hospital Medical College, Alexandra Wing, Royal London 
Hospital, Whitechapel, London E1 1BB. (Tel: 0171 377 7725) or 
email Jon Stamford (j.stamford at lhmc.ac.uk)

Closing date: 31st July 1995

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