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About:Adenovirus-vectors/in-vivo CNS transfection

Richard Kerr kerrr at CRYPTIC.RCH.UNIMELB.EDU.AU
Mon Jul 24 22:44:57 EST 1995


Hi Berend, it sounds like you are just kicking off an interesting piece of work.
Is there any chance of you posting a summary of responses on the board as
this area has been a great talking point at my place & I'd like to get some
input about       Safety issues
                Advantages and drawbacks
                Relevant literature
& also what is best: liposomes Vs adenovirus
from the informal chat  there seems to be a big problem with the
immunogenicity of the virus shell on repeat treatment , leading to liver
scarring & ultimately dysfunction ( so if the therapy is to work, it has to
work first time). I don't know of any work that identifies the major
antigens responsible for the effect though.
A lit. search using Alexander IA as an author may turn up some goodies.
so how about a summary post? 

CHEERS 
RICHARD






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