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Frontal lobes and Mania

David dhe at er7.rutgers.edu
Fri Jul 28 17:59:30 EST 1995

royster367 at aol.com (Royster367) writes:

>Would anyone have any ideas on possible pharmacologic treatments in a
>patient who exhibits manic symptamatology which resulted from right
>frontal lobe damage? Any suggestions would be greatly appreciated.

The usual gang of antimanics and mood stabilizers: Tegretol,
valproate, or lithium.  So says a review by Harvey Levin and Marilyn
F. Kraus in the winter '94 issue of _Journal of Neuropsychiatry and
Clinical Neuroscience_.  They also say that disinhibition (which I'll
read as roughly equivalent to "manic symptomatology") can be treated
with SSRIs, buspirone, trazodone, and/or high doses of beta-blockers.
Perhaps counterintuitively, there have been reports of success with
dopamine agonists.  Neuroleptics should be avoided, say Levin & Kraus,
because neuroleptics can exacerbate symptomatology and slow cortical


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